arXiv:2611.13330v1 Announce Type: new Abstract: Accurate localization of abnormalities in three-dimensional (3D) CT scans is essential for linking automated predictions with clinically relevant pathological findings. We propose Uni-Loc, a vision-language framework that unifies pathology classification and 3D localization using scan-level supervision. Uni-Loc derives both predictions and localization maps from spatial similarities between pathology-conditioned queries and image features. A token-to-voxel upsampling module enables high-resolution localization, while gradient-guided thresholding identifies pathology regions without additional learned parameters. Evaluated on five localization tasks comprising 355 annotated CT scans, Uni-Loc achieves macro-averaged voxel-level AUROC/AUPR of 96.1\%/34.5\%, outperforming relevance propagation (80.7%/13.9%) and gradient saliency (88.7%/8.1%). Uni-Loc also achieves classification AUROC of 88.39% on CT-RATE and 78.03% on RAD-ChestCT, improving over a matched baseline. These results demonstrate effective 3D pathology localization without requiring pathology-specific voxel-level supervision.