arXiv:2509.09906v2 Announce Type: replace-cross Abstract: Risk negotiation under the One Health framework requires balancing competing stakeholder interests across human, animal, and environmental health domains - a process constrained by information complexity and time pressure. This study presents and evaluates a multi-step pipeline that integrates large language model-based agents into a human-supervised negotiation process, specifically targeting risk assessment, valuation, and negotiation steps. Agent descriptions were generated from stakeholder-provided materials using retrieval-augmented generation methods. During preliminary multi-agent discussions, agents accessed domain-specific computational models and web-based sources before human participants refined proposed issues and options. A simulated negotiation game then produced distributions of candidate deals, characterised using Nash bargaining solution criteria and Pareto optimality metrics. The developed approach was evaluated in a workshop involving independent domain experts across two real-world scenarios: food safety criteria for Campylobacter in broiler meat and oak processionary moth management. In this feasibility evaluation, participants reached consensus with the allotted time after discussing and modifying the proposed deals. The framework offers an adaptable blueprint for AI-assisted risk negotiation; the specific contribution of LLM assistance, including gains in efficiency and decision quality, requires comparative evaluation.