arXiv:2511.11678v1 Announce Type: cross Abstract: The surge in intelligent applications driven by large language models (LLMs) has made it increasingly difficult for bandwidth-limited cloud servers to process extensive LLM workloads in real time without compromising user data privacy. To solve these problems, recent research has focused on constructing cloud-edge consortia that integrate server-based LLM with small language models (SLMs) on mobile edge devices. Furthermore, designing collaborative training mechanisms within such consortia to enhance inference performance has emerged as a promising research direction. However, the cross-domain deployment of SLMs, coupled with structural heterogeneity in SLMs architectures, poses significant challenges to enhancing model performance. To this end, we propose Co-PLMs, a novel co-tuning framework for collaborative training of large and small language models, which integrates the process of structure-agnostic mutual learning to realize knowledge exchange between the heterogeneous language models. This framework employs distilled proxy models (DPMs) as bridges to enable collaborative training between the heterogeneous server-based LLM and on-device SLMs, while preserving the domain-specific insights of each device. The experimental results show that Co-PLMs outperform state-of-the-art methods, achieving average increases of 5.38% in Rouge-L and 4.88% in EM.